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. Author manuscript; available in PMC: 2012 Mar 22.
Published in final edited form as: Nat Neurosci. 2009 Dec 27;13(2):190–196. doi: 10.1038/nn.2476

Figure 7.

Figure 7

Dendritic secretion of Aβ reduces local spine structural plasticity. (a) EGFP-labeled spines before and after cLTP induction. Left, spines more than 50 µm away from APP-labeled structures. Right, EGFP-labeled spines within 3 µm of an APP-labeled dendrite. Scale bar represents 1 µm. (b) The volume change of spines >50 µm from APP dendrites and of those <3 µm from APP dendrites before, during and after cLTP induction (>50 µm from APP dendrite: n = 194 spines, 42 slices; <3 µm from APP dendrite: n = 243 spines, 42 slices; ANOVA, F = 33.1, P < 0.0001; t test between >50 um from APP dendrite and <3 um from APP dendrite, *P < 0.01). (c) Bar graph of spine volume change after cLTP (log transformed) in groups of spines 0–3 µm, 3–6 µm, 6–20 µm or >50 µm from APP dendrites (0–3 µm: 0.079 ± 0.011, 358 spines; 3–6 µm: 0.101 ± 0.013, 235 spines; 6–20 µm: 0.134 ± 0.016, 180 spines; >50 µm: 0.143 ± 0.009, 580 spines, from 68 slices; ANOVA, F = 7.77, P < 0.0001; t test, *P = 0.008, **P < 0.001). Error bars represent s.e.m.