Table 3. Isolated Yields, Enzyme Inhibition Data, and Antiviral Activity for Compounds 19a–e^a.

^aFor conditions, see Scheme 8. The asterisk (∗) indicates not determined.

^bIsolated yields of 19a for the deprotection step, and isolated yields of 19b–e for the coupling–deprotection step.

^cATZ: K_i = 2.7 nM.³⁷

^dATZ: EC₅₀ = 0.0039 mM.³⁷

^eATZ Cl_int = 90 μL min^–1 mg^–1 23 [140 μL min^–1 mg^–1 64].

^fATZ P_app(Caco-2) = 5.3 × 10^–6 cm/s.