Figure 2:

Complexity of domain interaction networks based on TIR domain. Predicted interaction networks relative to the TIR domain. Extensive complexity is indicated among amphioxus, sea urchin and human topologies of innate protein interactions. Common domain combinations between the selected genomes are shown in gray; amphioxus-specific combinations are shown in red; human-specific combinations are shown in blue and sea urchin-specific combinations are shown in green. It is predicted that novel domain combinations result in functionally relevant, innate immune topology for inflammatory pathways in amphioxus. Figure 2 is reproduced from [53], an open access article.