Table 3.
Subgroups and sensitivity analysis based on ORs of ECG outcomes.
| Group | No. of studies | No. of participants | OR | Wilcoxon test | 95% CI | Z | P (effect) | I 2 | χ 2 | P (het) | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| M score | ≤3 | 3 | 252 | 2.73 | W = 4 | 1.52, 4.91 | 3.35 | 0.0008 | 0% | 0.24 | 0.89 |
| >3 | 2 | 118 | 1.65 | P = 0.5637 | 0.49, 5.57 | 0.8 | 0.42 | 49% | 1.98 | 0.16 | |
| Sample size | <78 | 3 | 154 | 1.71 | W = 2 | 0.77, 3.84 | 1.31 | 0.19 | 0% | 1.93 | 0.38 |
| ≥78 | 2 | 216 | 2.84 | P = 0.5637 | 1.56, 5.20 | 3.39 | 0.0007 | 0% | 0 | 0.99 | |
| No. of authors | 1 | 3 | 276 | 2.91 | W = 6 | 1.65, 5.14 | 3.69 | 0.000 2 | 0% | 0.05 | 0.97 |
| >1 | 2 | 94 | 1.39 | P = 0.0833 | 0.54, 3.55 | 0.68 | 0.5 | 4% | 1.05 | 0.31 | |
| Publication year | <2005 | 2 | 166 | 1.75 | W = 1 | 0.54, 5.74 | 0.93 | 0.35 | 60% | 2.47 | 0.12 |
| ≥2005 | 3 | 204 | 2.69 | P = 0.2482 | 1.29, 5.60 | 2.63 | 0.008 | 0% | 0.24 | 0.89 | |
| Trial date | Reported | 2 | 118 | 1.65 | W = 2 | 0.49, 5.57 | 0.8 | 0.42 | 49% | 1.98 | 0.16 |
| Not reported | 3 | 252 | 2.73 | P = 0.5637 | 1.52, 4.91 | 3.35 | 0.0008 | 0% | 0.24 | 0.89 | |
| Comparable | Reported | 4 | 238 | 2.06 | W = 2 | 1.08, 3.93 | 2.19 | 0.03 | 0% | 2.48 | 0.48 |
| Not reported | 1 | 132 | 2.83 | P = 1 | 1.37, 5.85 | 2.81 | 0.005 | NA | NA | NA | |
| AEs | Reported | 3 | 250 | 2.22 | W = 2 | 1.14, 4.32 | 2.33 | 0.02 | 25% | 2.66 | 0.26 |
| Not reported | 2 | 120 | 2.54 | P = 0.5637 | 0.94, 6.90 | 1.83 | 0.07 | 0% | 0.21 | 0.65 | |
| Improvement | >50% | 5 | 370 | 2.37 | W = 14 | 1.46, 3.84 | 3.5 | 0.0005 | 0% | 2.90 | 0.57 |
| >80% | 5 | 370 | 1.60 | P = 0.7540 | 0.98, 2.60 | 1.88 | 0.06 | 0% | 2.38 | 0.67 |
CI is confidence interval. NA is not available; Mann-Whitney-Wilcoxon test was performed on ORs of ECG. Z and P (effect) evaluated the statistics of overall effect; I 2, χ 2, and P (het) were computed to assess heterogeneity.