Table 1.
Body weights, Open Field, and Elevated Zero Maze Performance
| Body | ||||||
|---|---|---|---|---|---|---|
| Weightsa Treatment | Sex | Weight Gain (g)(P20–P11) | Weight (g) PD21 | Sex | Weight Gain (g)(P20–P11) | Weight (g) PD21 |
| SA | F | 2.644±0.308 | 7.844±0.450 | M | 2.633±0.233 | 7.941±0.465 |
| THIO | F | 3.270±0.396 | 8.080±0.198 | M | 3.250±0.102 | 8.60±0.305 |
| MA | F | 2.756±0.154 | 8.033±0.267 | M | 2.958±0.164 | 8.667±0.210 |
|
| ||||||
| Open Field b | ||||||
| Treatment | Sex | Distance Moved (cm) | % Time in Center | Sex | Distance Moved (cm) | % Time in Center |
| SA | F | 4406.9±466.86 | 9.463±1.37 | M | 3903.98±133.26 | 11.525±1.48 |
| THIO | F | 4894.58±313.09 | 9.606±1.37 | M | 3909.695±260.58 | 8.521±1.623 |
| MA | F | 4064.95±399.123 | 7.62±0.929 | M | 3693.5±181.211 | 9.550±1.532 |
|
| ||||||
| Elevated | ||||||
| ZeroMazec Treatment | Sex | Distance Moved (cm) | % Time in Open Areas | Sex | Distance Moved (cm) | % Time in Open Areas |
|
| ||||||
| SA | F | 1868.457±84.606 | 22.032±2.544 | M | 1647.277±62.709 | 20.993±3.937 |
| THIO | F | 1895.627±97.535 | 24.027±2.777 | M | 1607.831±34.927 | 19.002±2.305 |
| MA | F | 1795.512±144.673 | 17.869±2.043 | M | 1605±109.92 | 19.829±2.290 |
All measures shown are averages ± SEM. SA=saline; MA=methamphetamine; THIO=thioperamide. N=8–12 mice/sex/treatment.
a
RM ANOVA indicated a main effect of postnatal day (P < 0.001) on weight gain and of treatment (p<0.05) with THIO-treated mice gaining significantly more weight than SA-treated mice.
b
ANOVA indicated that in the open field
c
elevated zero maze female mice moved more than male mice, regardless of treatment (P < 0.05) and P < 0.001; respectively).