Table 4.
Treatment | Sex | Baselinea | Contextual test | Pre-tone cued testa | During tone cued test |
---|---|---|---|---|---|
SA | M | 23.866±2.165 | 46.521±4.630 | 31.067±4.619 | 62.677±4.728 |
THIO | M | 24.786±2.232 | 49.440±4.114 | 30.617±2.311 | 67.949±4.238 |
MA | M | 21.410±1.378 | 48.076±3.371 | 30.970±2.837 | 70.075±1.882 |
SA | F | 17.593±1.784 | 44.800±6.186 | 25.796±3.125 | 63.728±3.869 |
THIO | F | 21.121±1.816 | 42.809±3.039 | 25.104±2.609 | 68.147±3.477 |
MA | F | 25.421±2.848 | 48.864±4.670 | 26.179±2.420 | 67.526±4.108 |
Data are expressed as mean percentages ± standard error of the mean. SA=saline; THIO=thioperamide; MA=methamphetamine. n = 8 mice/sex/treatment.
Trend for a sex*treatement interaction (P = 0.055). MA-treated females showed slightly more freezing during baseline than SA- and THIO-treated females. This was not seen in male mice.
Trend for females to freeze less than males during pre-tone cued test (P = 0.099).