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. Author manuscript; available in PMC: 2013 Mar 21.

Published in final edited form as: J Am Chem Soc. 2012 Mar 5;134(11):5131–5137. doi: 10.1021/ja209390d

Table 1.

Catalytic asymmetric synthesis of pyrroloindolines.


entry		ee (%)^a (exo/endo)^b
1)	3a 86% yield dr = 4:1	94/91
2)	3b 93% yield dr = 3:1	93/92
3)	3c 61% yield dr = 3:1	93/90
4)	3d 84% yield dr = 5:1	94/91
5)	3e 91% yield dr = 4:1	94/90
6)	3f 54% yield dr = 6:1	92/90
7)	3g 80% yield^c dr = 4:1	92/90
8)	3h 65% yield dr = >18:1	86
9)	3i 90% yield^c dr = 3:1	93/90
10)	3j 18% yield dr = 8:1	95/93

^a

Determined by chiral stationary phase SFC or HPLC.

^b

Determined by ¹H NMR analysis of mixture.

^c

1.6 equiv SnCl₄ were employed.