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. Author manuscript; available in PMC: 2013 Mar 21.
Published in final edited form as: J Am Chem Soc. 2012 Mar 5;134(11):5131–5137. doi: 10.1021/ja209390d

Table 3.

Catalyst optimization.a

graphic file with name nihms361777u3.jpg
entry catalyst loading (mol %) yield (%)b ee (%)c
1 9a 20 86 81
2 9b 20 17 37
3 9c 20 83 87
4 9d 20 76 84
5 9e 20 85 90
6 9f 20 76 93
7 9g 20 7 1
8 9h 20 86 54
9 9i 20 88 78
10 9j 20 82 78
11 9f 40 76 93
12 9f 15 77 93
13 9f 10 75 92
14 9f 5 72 88
a

Reactions conducted under inert atmosphere on 0.2 mmol scale for 2 h.

b

Isolated yield.

c

Determined by chiral stationary phase SFC.