Table I. Comparison of clinical assessment of inflammation, amounts of S. aureus, and levels of LTA and SPA and cytokines in MRSA versus MSSA-positive AD lesions.

The EASI score of the tested lesion and total body EASI scores, concentration of S. aureus bacteria, LTA, SPA and cytokine levels were compared in samples which the bacterial isolate was sensitive (MSSA) or resistant (MRSA) to the antibiotic oxacillin. Each of the above are the mean, (SD) and [median].

Variable	MSSA-Visit 1 (N = 50)	MRSA-Visit 1 (N = 9)	MSSA-Visit 2 (N = 50)	MRSA-Visit 2 (N = 9)
EASI-Lesional	9.8 (1.7) [9.0]	10.6 (1.7) [11]	4.5 (1.8) [4.0]*	3.7 (2.5) [2.0]*
EASI-Total	19 (11) [22]	33.4 (24) [28]	4.8 (4.4) [3.3]*	6.3 (5.2) [5.0]*
Log [SA] (CFU/ml)	6.1 (1.4) [6.4]	7.0 (1.0) [6.9]#	1.7 (2.3) [0]*	1.9 (2.5) [1.0]*
[LTA] (pg/cm3)	1024 (1892) [274]	1466 (2150) [624]	ND: 92%*	ND: 78%*
[SPA] (pg/cm3)	17 (52) [1.1]	15 (28) [8.4]	1.5 (8) [0.02]*	1.5 (3.4) [0]*
[IL-1β] (pg/cm3))	133 (457) [40]	96 (126) [52]	15 (33) [4.0]*	18 (21) [16]*
[IL-4] (pg/cm3)	21 (42) [3.8]	9.8 (14) [0.8]	ND: 88%*	ND: 56%
[IL-5] (pg/cm3)	58 (231) [2.9]	1.8 (1.9) [1.7]	ND: 84%*	ND: 100%
[IL-6] (pg/cm3)	338 (502) [131]	582 (874) [338]	23 (48) [3.4]*	28 (55) [1.0]*
[IL-8] (pg/cm3)	10190 (15034) [4935]	7924 (10826) [4598]	2054 (6364) [180]*	678 (779) [545]*
[IL-10] (pg/cm3)	2.2 (3.6) [0.1]	1.6 (2.3) [0.3]	ND: 96%*	ND: 89%
[IL-12] (pg/cm3)	ND: 92%	ND: 100%	ND: 96%	ND: 100%
[IL-13] (pg/cm3)	214 (861) [15]	22 (23) [11]	30 (101) [0.6]*	2.3 (4.8) [0]*
[IL-17] (pg/cm3)	23 (65) [2.5]	0.5 (1.1) [0]	ND: 60%*	ND: 67%
[TNF-α] (pg/cm3)	47 (48) [29]	47 (31) [47]	8.2 (15.7) [3.0]*	4.4 (5.9) [1.3]*
[IFN-γ] (pg/cm3)	ND: 94%	ND: 96%	ND: 96%	ND: 100%

^#Denotes that the CFU of MRSA is statistically (p = 0.049) greater than MSSA at visit 1;

^*Denotes that the reduction at visit 2 from visit 1 within each group was significant, p < 0.05. ND: non-detectable.