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. Author manuscript; available in PMC: 2013 Apr 21.
Published in final edited form as: Behav Brain Res. 2012 Feb 2;230(1):34–39. doi: 10.1016/j.bbr.2012.01.042

Figure 1. Acquisition of nicotine or saline self-administration.

Figure 1

After catheter implantation and recovery, mice were trained to nose-poke for infusions of nicotine (0.03 mg/kg/infusion) (A) or saline (B). The schedule of reinforcement was maintained at a fixed ratio 1 (FR1) for a period of 6 sessions, followed by a FR2 schedule for a period of 4 sessions. Data is shown as mean (±SEM) number of nose-pokes or infusions. *p<0.05, **p<0.01, ***p<0.001, a two-way ANOVA followed by Bonferroni post hoc analysis.