Table 2.
Socio-demographic variables, alcohol intake and problem drinking in men by ADH1B genotype.
| All | ADH1B
|
p-value | ||
|---|---|---|---|---|
| ArgArg | His carriers | |||
| No. of subjects | 3016 | 2695 | 321 | |
| Mean age, years (SD) | 58.3 (7.1) | 58.3 (7.2) | 58.3 (6.8) | 0.847 |
| Smoking (%) | 25.9 | 25.9 | 25.9 | 0.999 |
| University educ. (%) | 18.1 | 17.7 | 21.7 | 0.169 |
| Drinking frequency (%) | ||||
| Never | 6.0 | 6.1 | 5.3 | 0.052 |
| <1/month | 17.2 | 16.6 | 22.4 | |
| 1–3/months | 17.4 | 17.4 | 17.5 | |
| 1–4/week | 36.8 | 37.0 | 35.8 | |
| 5+/week | 22.6 | 23.0 | 19.0 | |
| Annual intake of alcohol (g) | ||||
| None | 6.0 | 6.0 | 5.2 | 0.073 |
| <3000 g | 46.0 | 45.4 | 50.6 | |
| 3000–5999 g | 14.4 | 14.4 | 14.1 | |
| 6000–11999 g | 15.8 | 15.7 | 16.6 | |
| 12000g+ | 18.0 | 18.6 | 13.5 | |
| Weekly alcohol intake (g) | ||||
| None | 13.8 | 13.2 | 19.2 | <0.001 |
| <100g | 28.6 | 28.2 | 31.9 | |
| 100–249g | 31.7 | 31.6 | 32.5 | |
| 250g+ | 25.9 | 27.0 | 16.4 | |
| Weekly alcohol intake (g) | 120 | 126 | 96 | <0.001 |
| Median (IQR)* | (40, 256) | (40,268) | (40, 200) | |
| Binge, ≥60g ≥1/month (%) | 36.7 | 37.1 | 33.0 | 0.151 |
| Binge, ≥100g ≥1/month (%) | 16.9 | 16.9 | 17.1 | 0.923 |
| Mean dose ≥60g per occasion | 18.6 | 19.0 | 15.9 | 0.181 |
| CAGE 2+ (%) | 9.5 | 9.7 | 7.6 | 0.232 |
| Negative consequences (%) | 9.1 | 9.1 | 8.8 | 0.867 |
*
IQR = interquartile range; statistical significance tested by Kruskal-Wallis rank test.