Table 3.
Socio-demographic variables, alcohol intake and problem drinking in women by AHD1B genotype.
| All | ADH1B
|
p-value | ||
|---|---|---|---|---|
| ArgArg | His carriers | |||
| No. of subjects | 3481 | 3104 | 377 | |
| Mean age, years (SD) | 57.4 (7.1) | 57.4 (7.1) | 57.3 (7.3) | 0.716 |
| Smoking (%) | 20.2 | 19.2 | 22.0 | 0.340 |
| University educ. (%) | 9.9 | 10.0 | 9.7 | 0.444 |
| Drinking frequency (%) | ||||
| Never | 16.6 | 16.2 | 19.4 | <0.001 |
| <1/month | 34.0 | 33.1 | 42.2 | |
| 1–3/months | 24.0 | 24.5 | 20.2 | |
| 1–4/week | 21.0 | 21.7 | 15.1 | |
| 5+/week | 4.3 | 4.5 | 3.2 | |
| Annual intake of alcohol (g) | ||||
| None | 16.6 | 16.2 | 19.4 | 0.002 |
| <1000 g | 54.4 | 53.6 | 60.7 | |
| 1000–2999 g | 16.5 | 17.0 | 11.9 | |
| 3000–5999 g | 6.7 | 7.0 | 4.5 | |
| 6000g+ | 5.9 | 6.2 | 3.5 | |
| Weekly alcohol intake (g) | ||||
| None | 47.6 | 46.2 | 58.7 | <0.001 |
| <100g | 38.4 | 39.3 | 31.5 | |
| 100–249g | 11.8 | 12.2 | 8.7 | |
| 250g+ | 2.2 | 2.4 | 1.1 | |
| Weekly alcohol intake (g) | 10 | 12 | 0 | <0.001 |
| Median (IQR)* | (0, 50) | (0,56) | (0, 40) | |
| Binge, ≥60g ≥1/month (%) | 9.6 | 9.9 | 6.9 | 0.060 |
| Binge, ≥100g ≥1/month (%) | 3.0 | 3.1 | 1.9 | 0.172 |
| Mean dose ≥60g per occasion | 5.7 | 6.0 | 3.5 | 0.047 |
| CAGE 2+ (%) | 2.1 | 2.2 | 1.3 | 0.284 |
| Negative consequences (%) | 3.6 | 3.7 | 2.6 | 0.301 |
*
IQR = interquartile range; statistical significance tested by Kruskal-Wallis rank test.