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. 2012 Mar 5;3:19. doi: 10.3389/fimmu.2012.00019

Figure 6.

Figure 6

Co-localization of post-Aire mTECs and HCs with epidermal autoantigens and APC markers. (A) Thymi from 4- to 6-week-old Aire+/− mice were stained for LacZ, DG-1, DG-3, LAMP-1, and CD11c. There was a clear co-localization of the (LacZ+) post-Aire cell population and the autoantigens DG-1 and DG-3. Also, the post-Aire cells were often surrounded by the LAMP-1+ and CD11c+ APCs. (B) Thymi from 5- to 6-week-old Aire+/− mice were stained for HCs with CK10 and DG-1, DG-3, LAMP-1, and CD11c. There was a clear co-localization of HCs and the epidermal autoantigens DG-1 and DG-3. Also, the HCs were often surrounded by the LAMP-1+ and CD11c+ APCs. In (B) DAPI was used for nuclear staining. Figures are representatives of at least three experiments, bars correspond to 40 μm.