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. Author manuscript; available in PMC: 2013 Apr 21.
Published in final edited form as: Behav Brain Res. 2012 Feb 13;230(1):158–166. doi: 10.1016/j.bbr.2012.02.010

Table 3. Dose-dependent effects of acute alcohol on p-ERK1/2 immunoreactivity 30- minutes after injection in adolescent and adult mouse brain.

Data are shown as percent change in mean ± SEM p-ERK1/2 IR as compared to parallel aged-matched saline controls at each dose of ethanol tested (n=8 per condition). * - indicates significantly different from corresponding saline control, P≤0.05. Values in bold text indicate adolescent-specific changes.

Age Brain regions 0.5 g/kg 1.0g/kg 3.0g/kg
Saline Ethanol Saline Ethanol Saline Ethanol
Adolescent Amygdala
Central 100 ± 17.46 110.65 ± 15.52 100 ± 14.92 106.6 ± 17.70 100 ± 9.43 460.34 ± 36.55*
Basolateral 100 ± 12.16 73.55 ± 8.52 100 ± 21.44 83.92 ± 13.87 100 ± 11.66 443 ± 27.54*
N. Accumbens
Core 100 ± 12.2 110.33 ± 14.85 100 ± 13.40 106.61 ± 12.35 100 ± 11.95 100 ± 15.50
Shell 100 ± 18.55 75.29 ± 13.89 100 ± 17.14 91.69 ± 16.78 100 ± 10.11 100 ± 12.94
mPFC 100 ± 7.35 101.47 ± 8.79 100 ± 6.31 104.26 ± 7.80 100 ± 3.86 176.60 ± 2.62*
Dentate Gyrus 100 ± 5.18 93.6± 1.7 100 ± 8.29 56.29 ± 6.11* 100 ± 4.21 35.2 ± 4.64*
Adult Amygdala
Central 100 ± 17.77 127.75 ± 16.18 100 ± 16.10 128.32 ± 12.82 100 ± 18.49 513.81 ± 77.18*
Basolateral 100 ± 23.06 53.01 ± 24.42 100 ± 27.03 127.08 ± 27.79 100 ± 9.22 121.38 ± 12.10
N. Accumbens
Core 100 ± 11.46 115.07 ± 18.62 100 ± 14.60 128.66± 18.66 100 ± 10.21 92.95 ± 15.55
Shell 100 ± 30.28 87.53 ± 16.10 100 ± 22.96 93.64 ± 18.04 100 ± 22.24 97.37 ± 10.41
mPFC 100 ± 8.91 96.92 ± 590.5 100 ± 7.61 105.84 ± 13.26 100 ± 5.48 139 ± 10.33*
Dentate Gyrus 100 ± 6.33 103.54 ± 5.60 100 ± 5.82 89.39± 10.04 100 ± 3.28 38.33 ± 5.05*
*

sig diff from saline p<0.05