Table 5.

Risk factor analysis for osteonecrosis after alloHCT

Univariate analysis using GEE model
Clinical Variables	Clinical Level	95% CI of OR	P Values
BMI at alloHCT	Normal Underweight	0.86(0.40 to 1.83)	0.6925
	Overweight Obese
Gender	Female	1.81(0.87 to 3.74)	0.1108
	Male
Race	Black	2.09(0.87 to 5.05)	0.1011
	Other	0.49(0.06 to 4.25)	0.5138
	White
Diagnosis type	Malignant	1.04(0.43 to 2.50)	0.9283
	Non-malignant
Primary Diagnosis	Lymphoid Malignancies + Aplastic Anemia	1.40(0.68 to 2.88)	0.3662
	Others
Age at alloHCT	Age at alloHCT <10	0.15(0.06 to 0.37)	<.0001
	Age at alloHCT >=10
Chronic GVHD grade	Extensive	1.33(0.55 to 3.21)	0.5302
	Limited	1.33 (0.48 to 3.64)	0.5819
	No chronic GVHD
Acute GVHD Maximum Overall Grade	No acute GVHD grade ≥ 1	0.82(0.32 to 2.12)	0.6834
Physis Status	Closed	3.33(1.55 to 7.15)	0.0020
	Open
Donor Type	Related	1.78(0.82 to 3.89)	0.1465
	Unrelated
Conditioning regimen	NO TBI	1.16(0.54 to 2.51)	0.7020
	TBI
Duration of Chronic GVHD, 6 months	No prior chronic GVHD
	Duration <= 6 month	1.29(0.56 to 2.95)	0.5455
	Duration > 6 month	1.42(0.44 to 4.58)	0.5546
Pre-alloHCT MR	Involved	14.19(3.52 to 57.27)	0.0002
	Not done/Missing	0.75(0.33 to 1.74)	0.5074
	Not involved
Multiple GEE model analysis⫲
Variable	Clinical Level	95% CI of OR	P Values
Pre-alloHCT MR	Involved	13.50(2.64 to 68.92)	0.0018
	Not Involved	0.86(0.30 to 2.51)	0.7867
	Not done/Missing
Physis	Closed	1.42(0.41 to 4.94)	0.5827
	Open
Age at alloHCT	Age at HCT <10	0.25(0.06 to 1.01)
	Age at HCT >=10	4.00 (1.00 to 16.7)	0.0518
Race	Black	2.64(0.82 to 8.52)	0.1046#
	Other	0.53(0.05 to 5.44)	0.5925#
	White
Gender	Female	1.10(0.42 to 2.86)	0.8462
	Male

Abbreviations: alloHCT, allogeneic hematopoietic stem cell transplantation; BMI, body mass index; GVHD, graft vs. host disease; TBI, total body irradiation; MR, magnetic resonance imaging

^⫲Only factors significant (0.1 significant level) from univariate GEE model were included in this model

^#For race analysis sickle cell patients were excluded.