Table 3.
Comparison of clinical parameters between low and high Fazekas scores
| Score grade | FDWMH | FPVH | |||||
|---|---|---|---|---|---|---|---|
|
|
|
||||||
| 0–1 | 2–3 | P value | 0 | 1–3 | P value | ||
| Number of patients | 110 | 75 | 83 | 102 | |||
| Age (years) | Mean (SD) | 67 (5) | 74 (6) | <0.0001 | 67 (5) | 72 (7) | <0.0001 |
| BMI (kg/m2) | Mean (SD) | 24.1 (3.6) | 24.6 (3.9) | 0.38 | 23.7 (3.3) | 24.9 (4.0) | 0.03 |
| Male | n (%) | 49 (45) | 35 (47) | 0.78 | 39 (47) | 45 (44) | 0.7 |
| Current or past smoking | n (%) | 34 (31) | 22 (29) | 0.82 | 29 (35) | 27 (26) | 0.21 |
| Hyperlipidemia | n (%) | 60 (55) | 41 (55) | 0.99 | 49 (59) | 52 (51) | 0.27 |
| Diabetes mellitus | n (%) | 23 (21) | 15 (20) | 0.88 | 18 (22) | 20 (20) | 0.73 |
| SBP (mmHg) | Mean (SD) | 139 (17) | 139 (16) | 0.78 | 138 (16) | 140 (17) | 0.28 |
| DBP (mmHg) | Mean (SD) | 79 (10) | 78 (11) | 0.58 | 79 (9) | 79 (11) | 0.67 |
| PP (mmHg) | Mean (SD) | 60 (13) | 61 (13) | 0.77 | 58 (12) | 62 (13) | 0.059 |
| CPP (mmHg) | Mean (SD) | 64 (16) | 64 (15) | 0.85 | 62 (16) | 66 (16) | 0.17 |
| SBP2 (mmHg) | Mean (SD) | 129 (19) | 131 (18) | 0.6 | 128 (18) | 132 (19) | 0.17 |
| CSBP (mmHg) | Mean (SD) | 144 (20) | 142 (20) | 0.66 | 142 (20) | 144 (21) | 0.4 |
| rAIx (%) | Mean (SD) | 85 (16) | 84 (12) | 0.63 | 84 (15) | 84 (14) | 0.88 |
| rAIx@75 (%) | Mean (SD) | 83 (13) | 83 (12) | 0.95 | 82 (13) | 84 (13) | 0.45 |
| HR/min | Mean (SD) | 71 (12) | 73 (10) | 0.14 | 71 (12) | 73 (10) | 0.14 |
| Serum creatinine (mg/dL) | Mean (SD) | 0.71 (0.16) | 0.83 (0.24) | <0.0001 | 0.71 (0.16) | 0.80 (0.23) | 0.007 |
| eGFR (mL/min/1.73 m2) | Mean (SD) | 74.1 (13.2) | 63.2 (14.5) | <0.0001 | 74.3 (12.4) | 65.9 (15.4) | <0.0001 |
| Duration of hypertension (years) | Median (interquartile range) | 10 (5–15) | 15 (8–20) | 0.0002 | 10 (5–15) | 12 (5.75–20) | 0.0059 |
Abbreviation: FDWMH, deep white-matter hypertintensities of Fazekas scale; FPVH, periventricular hyperintensites of Fazekas scale; BMI, body mass index; SBP, brachial systolic blood pressure; DBP, brachial diastolic blood pressure; PP, brachial pulse pressure; CPP, central pulse pressure; SBP2, secondary systolic blood pressure; CSBP, central systolic blood pressure; rAIx, radial augmentation index; rAIx@75, radial augmentation index normalized for a heart rate of 75/min; HR, heart rate; eGFR, estimated glomerular filtration rate.