Table 4.
Comparison of clinical parameters between low and high Scheltens scores
| Score grade | SDWMH frontal | SDWMH parietal | SDWMH occipital | SDWMH temporal | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
|
|
||||||||||
| 0–2 | 3–6 | P value | 0–2 | 3–6 | P value | 0–2 | 3–6 | P value | 0–2 | 3–6 | P value | ||
| Number of patients | 164 | 21 | 112 | 73 | 165 | 20 | 181 | 4 | |||||
| Age (years) | Mean (SD) | 69 (6) | 74 (7) | 0.005 | 68 (5) | 73 (7) | <0.0001 | 70 (7) | 73 (5) | 0.03 | 70 (7) | 66 (3) | 0.2 |
| BMI (kg/m2) | Mean (SD) | 24.4 (3.8) | 24.0 (3.2) | 0.7 | 24.1 (3.5) | 24.7 (4.1) | 0.28 | 24.4 (3.7) | 23.6 (4.1) | 0.33 | 24.3 (3.8) | 24.2 (2.5) | 0.95 |
| Male | n (%) | 71 (43) | 13 (62) | 0.11 | 53 (47) | 31 (42) | 0.52 | 72 (43) | 12 (60) | 0.7 | 81 (45) | 3 (75) | 0.23 |
| Current or past smoking | n (%) | 48 (29) | 8 (38) | 0.41 | 35 (31) | 21 (29) | 0.72 | 50 (30) | 6 (30) | 0.21 | 54 (30) | 2 (50) | 0.39 |
| Hyperlipidemia | n (%) | 92 (56) | 9 (43) | 0.25 | 61 (54) | 40 (55) | 0.96 | 91 (55) | 10 (50) | 0.27 | 97 (54) | 4 (100) | 0.07 |
| Diabetes mellitus | n (%) | 34 (21) | 4 (19) | 0.86 | 26 (23) | 12 (16) | 0.26 | 34 (21) | 4 (20) | 0.73 | 38 (21) | 0 (0) | 0.3 |
| SBP (mmHg) | Mean (SD) | 139 (17) | 136 (15) | 0.34 | 139 (17) | 140 (17) | 0.75 | 139 (17) | 138 (14) | 0.28 | 139 (17) | 141 (15) | 0.81 |
| DBP (mmHg) | Mean (SD) | 79 (10) | 79 (11) | 0.96 | 79 (10) | 79 (11) | 0.99 | 79 (10) | 81 (11) | 0.67 | 79 (10) | 89 (9) | 0.06 |
| PP (mmHg) | Mean (SD) | 61 (13) | 58 (13) | 0.43 | 60 (12) | 61 (14) | 0.54 | 61 (13) | 57 (11) | 0.059 | 60 (13) | 53 (9) | 0.23 |
| CPP (mmHg) | Mean (SD) | 65 (16) | 61 (14) | 0.3 | 64 (16) | 65 (16) | 0.63 | 64 (16) | 63 (14) | 0.17 | 64 (16) | 55 (14) | 0.25 |
| SBP2 (mmHg) | Mean (SD) | 130 (19) | 129 (17) | 0.79 | 129 (18) | 132 (19) | 0.31 | 129 (19) | 134 (16) | 0.17 | 130 (18) | 132 (19) | 0.75 |
| CSBP (mmHg) | Mean (SD) | 144 (20) | 140 (17) | 0.43 | 143 (20) | 144 (20) | 0.71 | 143 (20) | 144 (18) | 0.4 | 143 (20) | 144 (20) | 0.95 |
| rAIx (%) | Mean (SD) | 85 (15) | 81 (14) | 0.28 | 84 (16) | 84 (13) | 0.96 | 84 (15) | 87 (10) | 0.88 | 84 (15) | 78 (16) | 0.36 |
| rAIx@75 (%) | Mean (SD) | 83 (13) | 81 (13) | 0.54 | 83 (13) | 83 (12) | 0.66 | 82 (13) | 86 (11) | 0.45 | 83 (13) | 79 (12) | 0.54 |
| HR (/min) | Mean (SD) | 71 (11) | 75 (11) | 0.12 | 71 (11) | 73 (10) | 0.18 | 72 (11) | 73 (8) | 0.14 | 72 (11) | 78 (12) | 0.29 |
| Serum creatinine (mg/dL) | Mean (SD) | 0.75 (0.20) | 0.84 (0.16) | 0.051 | 0.73 (0.17) | 0.81 (0.24) | 0.006 | 0.76 (0.21) | 0.79 (0.18) | 0.48 | 0.76 (0.20) | 0.89 (0.12) | 0.21 |
| eGFR (mL/minute/1.73 m2) | Mean (SD) | 70.5 (0.20) | 63.2 (12.2) | 0.03 | 73.3 (13.7) | 64.2 (14.5) | <0.001 | 69.9 (14.8) | 68.1 (13.7) | 0.6 | 69.9 (14.8) | 62.5 (4.4) | 0.32 |
| Duration of hypertension (years) | Median (interquartile range) | 10 (5–19.5) | 15 (10–25) | 0.009 | 10 (5–15) | 15 (9–20) | 0.0014 | 10 (5–20) | 13.5 (6.5–19.25) | 0.48 | 10 (5–20) | 12.5 (2.75–34.25) | 0.91 |
Abbreviations: SDWMH, deep white-matter hypertintensities of Scheltens scale; BMI, body mass index; SBP, brachial systolic blood pressure; DBP, brachial diastolic blood pressure; PP, brachial pulse pressure; CPP, central blood pressure; SBP2, secondary systolic blood pressure; CSBP, central systolic blood pressure; rAIx, radial augmentation index; rAIx@75, radial augmentation index normalized for a heart rate of 75/minute; HR, heart rate; eGFR, estimated glomerular filtration rate.