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. Author manuscript; available in PMC: 2012 Mar 22.
Published in final edited form as: Cell Metab. 2010 Dec 1;12(6):654–661. doi: 10.1016/j.cmet.2010.11.003

Figure 5. β-Hydroxybutyrate Production Is Decreased in SIRT3KO Mice.

Figure 5

(A) β-Hydroxybutyrate (β-OHB) levels in SIRT3KO and WT mice at 1, 3, and 12 months of age after a 24 hr fast; n = 5–10 for each genotype ± SEM †(Hirschey et al., 2010), *p < 0.05.

(B) Serum β-hydroxybutyrylcarnitine levels in SIRT3KO mice compared to WT at 3 months of age after a 24 hr fast; n = 5 for each genotype ± SEM, **p < 0.01. (C) Proposed model for regulation of HMGCS2 by acetylation and deacetylation by SIRT3.