Figure 10.

Kainate-induced cell death in the hippocampus is dramatically reduced in Nrb^−/− mice. Hippocampal slices were collected from WT and Nrb^−/− mice 7 d after indicated treatment and stained with hematoxylin and eosin (HE, A–C). Cell death was detected by Fluoro-Jade B (FJB) staining (D–F) and TUNEL assay (G–I). Significant neuronal cell death was detected in the hippocampus of WT mice that received kainate (KA) administration, but not in the hippocampus of Nrb^−/− mice that underwent the same treatment.