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. Author manuscript; available in PMC: 2012 Mar 22.
Published in final edited form as: Biochim Biophys Acta. 2010 Feb 20;1804(8):1617–1625. doi: 10.1016/j.bbapap.2010.02.007

Figure 3. Model for the role of OAADPr in facilitating Sir complex assembly and loading onto the chromatin.

Figure 3

OAADPr interaction with the Sir2-4 complex facilitates loading of the complex onto nucleosomes, probably through binding to Sir2/Sir3. OAADPr might bind Sir3 alone and promote Sir3 loading onto nucleosomes.