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. Author manuscript; available in PMC: 2012 Mar 22.
Published in final edited form as: Biochim Biophys Acta. 2010 Feb 20;1804(8):1617–1625. doi: 10.1016/j.bbapap.2010.02.007

Figure 5. OAADPr and ADPr modulates calcium influx through TRPM2 channel.

Figure 5

In mammalian cells, OAADPr produced by sirtuins binds the NudT9H domain of TRPM2 and induces calcium influx into the cells. ADPr, another metabolite of NAD+, is believed to gate TRPM2 in a similar mechanism as OAADPr.