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. Author manuscript; available in PMC: 2012 Mar 22.
Published in final edited form as: Biochim Biophys Acta. 2010 Feb 20;1804(8):1617–1625. doi: 10.1016/j.bbapap.2010.02.007

Figure 6. OAADPr metabolism and proposed functions in S. cerevisiae.

Figure 6

OAADPr is produced by sirtuins and can be metabolized by Ysa1, an unknown esterase, and unknown acetyl transferase. Cells lacking Ysa1 display accumulation of ADPr/OAADPr and a corresponding decrease in AMP. Increased ADPr/OAADPr levels might protect cells against ROS via inhibition of the ETC and generation of higher NADPH levels from increased flux through the pentose phosphate pathway.