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. Author manuscript; available in PMC: 2012 Mar 22.
Published in final edited form as: Immunol Res. 2011 May;50(1):78–86. doi: 10.1007/s12026-010-8200-z

Table 2.

Cellular alterations post-BMT

Cell Type Baseline alterations post-HSCT Further alterations observed post-infection
Alveolar macrophages ↑PGE2, IRAK-M, GM-CSF, PTEN activity
↓TNFα, CysLTs		 In response to P. aeruginosa:
↓ Phagocytosis& killing
Lung neutrophils ↑PGE2 ↓Bacterial killing
CD4T cells ↓Responsein MLR
↑Lung Tregs		 In response to γHV-68:
↓Th1
↑Th17
Alveolarepithelial cell: ↑TGFβ
↑PGE2, GM-CSF		 In response to P. aeruginosa:
↓ GM-CSF, CCL2
Bone marrow-derived dendritic cells ↑ IL-10
↓ IL-12p70
↑Responsein MLR

This table summarizes alterations in specific cell types that we have observed in our BMT model both pre- and post-infection