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. 2012 Mar 21;7(3):e33778. doi: 10.1371/journal.pone.0033778

Figure 5. miR-34a inhibits pulmonary metastasis of osteosarcoma in vivo.

Figure 5

(A) Representative macroscopic pictures of mouse lungs, 42 days after inoculation. (B) Graph displaying the total number of tumor nodules per lung in control group (stable SOSP-9607 cells transfected with pcDNA3.1) and miR-34a group (stable SOSP-9607 cells transfected with pcDNA-miR34a.). Data are presented as means±SD. *P<0.01 (n = 6) is considered as statistically significant. (C) Representative photographs of H&E stained spontaneous lung metastases. The results showed that most of the tumor nodules were organized in a predominantly peripheral distribution in both groups. However, tumor nodules (arrows) in miR-34a group were smaller and distributed in a lower concentration as comparing with control group.