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. 2012 Mar 14;7:1329–1343. doi: 10.2147/IJN.S27159

Figure 9.

Figure 9

Effect of silver NPs on airway responsiveness to inhaled methacholine in ovalbumin-sensitized and ovalbumin-challenged mice. Airway hyperresponsiveness was measured at 24 hours after the final challenge in saline-inhaled mice administered saline (SAL), saline-inhaled mice administered 40 mg/kg of silver NPs (Ag40) or SU5614 (SU5614), ovalbumin-inhaled mice administered saline (OVA), and ovalbumin-inhaled mice administered 40 mg/kg of silver NPs (OVA+Ag40) or SU5614 (OVA+SU5614).

Notes: Penh values were obtained in response to increasing doses (from 2.5 to 25 mg/mL) of methacholine. Bars indicate the mean ± standard error of the mean for eight mice per group in four to six independent experiments. *P < 0.05 versus OVA; #P < 0.05 versus SAL.

Abbreviations: NP, nanoparticle; Penh, enhanced pause.