Table 1.

Samples, dosage, routes and number of doses used in the different experimental groups

Experimental group	Formulation	Route of administration	Number of dosesa	Timeb (minutes)
siRNA/G7	Buffer	Intravenous	1	90
siRNA/G7	Buffer	Intranasal	1	90
siRNA/G7	Buffer	Intranasal	2	180
siRNA/Lipofectamine™ 2000	Buffer	Intranasal	2	180
siRNA/G7	PxCBP	Intranasal	1	90
siRNA/G7	PxCBP	Intranasal	2	180
siRNA/Lipofectamine 2000	PxCBP	Intranasal	2	180
Naked siRNA	PxCBP	Intranasal	2	180

Notes:

^aThe two doses were administered with a 90-minute interval;

^btime between first administration and sacrifice.

Abbreviations: siRNA, small interfering RNA; G7, generation 7 dendrimers; PxCBP, poloxamer/carbopol gel.