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Extracted ion chromatograms of etravirine metabolites formed by HLMs. HLMs (2 mg/ml) were incubated with 20 μM ETR for 30 min at 37°C in the presence of an NADPH-regenerating system and UDPGA. Metabolites were detected using UPLC-MS in multiple reaction monitoring mode, by means of the following transitions: 451.3 → 304.1 m/z (M1 and M2), 451.3 → 353.1 m/z (M3), 467.3 → 369.1 m/z (M4, M5, and M6), and 627.1 → 338.1 m/z (M7). Data shown are representative of three individual experiments.
