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. 2012 Apr;341(1):43–50. doi: 10.1124/jpet.111.186833

Fig. 3.

Fig. 3.

Salsolinol depresses eIPSCs in putative dopamine neurons. A, salsolinol (0.1 μM) sharply reduced the peak amplitude of both the first and second IPSC evoked by paired stimulation (at 50-ms interval) within the VTA, but the greater relative reduction of the first response increased the ratio of IPSC2/IPSC (PPR). Labels a-c refer to times in B. B, time course of salsolinol-induced changes in eIPSC amplitude (Amp). C, summary of the effects of salsolinol (0.1 μM) on the amplitude and the PPR of eIPSCs; numbers of recorded neurons are in parentheses. *, p < 0.01, paired t test for salsolinol application versus presalsolinol control. All IPSCs were recorded from putative dopamine neurons at a VH of −70 mV in the presence of APV (50 μM) and DNQX (20 μM).