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. 2012 Apr;341(1):33–42. doi: 10.1124/jpet.111.187963

Fig. 7.

Fig. 7.

Linear relationship between EtOH effects on sIPSCs and discharge of VTA DA neurons. A, traces from a-VTA DA cell show baseline firing (Control) and the effects of gabazine, gabazine and 86 mM EtOH (gabazine + EtOH), 86 mM EtOH (EtOH) alone, and after washout of all drugs (Wash). B, summary of inhibition of a-VTA DA neuron firing by EtOH (86 mM) in the absence (control; n = 18) and presence of 10 μM gabazine (n = 15). C, summary of membrane hyperpolarization of a-VTA DA neurons induced by EtOH (86 mM) in the absence (Control; n = 18) and presence of 10 μM gabazine (n = 15). D, scatter plot of EtOH effects on the discharge of both a-VTA and p-VTA DA neurons against EtOH's effects on sIPSC frequency. Each point corresponds to the effects of one concentration of EtOH on firing rate and sIPSC frequency. EtOH concentrations are indicated. The points above the dashed line are the averaged effects of EtOH on p-VTA DA neurons; those below the dashed line are the averaged effects of EtOH on a-VTA DA neurons. These points were fitted by a linear equation (y = a + bx), with a correlation coefficient of 0.991 (P < 0.0001).