TABLE 1.
Electrophysiological and pharmacological properties of a-VTA and p-VTA DA neurons
| a-VTA |
p-VTA |
|||
|---|---|---|---|---|
| Mean ± S.E.M. | n | Mean ± S.E.M. | n | |
| 10 μM DA-induced Vm change, mV | −6.8 ± 1.1 | 9 | −7.8 ± 2.1 | 10 |
| Ongoing firing, Hz | 1.2 ± 0.3 | 56 | 1.3 ± 0.3 | 56 |
| Current spike width, ms | 3.8 ± 0.8 | 50 | 2.2 ± 0.7 | 47 |
| Peak Ih, pA | 169 ± 11 | 62 | 107 ± 18 | 68 |
| Action potential amplitude, mV | 64 ± 3 | 25 | 65 ± 4 | 5 |
| Resting membrane potential, mV | −52.6 ± 3.2 | 5 | −50.5 ± 1.8 | 6 |
| Gabazine-induced change in firing rate, % | 29 ± 11 | 15 | 47 ± 17 | 14 |