Table 2.

Summary of the secondary outcomes implemented in ARCLI across all time points

	Training	Baseline	3 month	6 month	12 month
Screening	Medical history & screen (GDS, MMSE, DRS-II) Demographic Q	Medical screen (ie BMI, MMSE, medication use)	Medical screen (ie BMI, MMSE, medication use)	Medical screen (ie BMI, MMSE, medication use)	Medical screen (ie BMI, MMSE, medication use)
Biochemical	Fasting Glucose & Insulin* APOE & SNP	F2 Isoprostanes Cytokines* & CRP MBA Telomere length	F2 isoprostanes Cytokines* & CRP MBA	-	F2 isoprostanes Cytokines* & CRP MBA Telomere length
Cardiovascular	-	Brachial BP Aortic BP carotid-femoral PWV	Brachial BP Aortic BP carotid-femoral PWV	Brachial BP Aortic BP carotid-femoral PWV	Brachial BP Aortic BP carotid-femoral PWV
Health	FFQ Chalder Fatigue Leeds Sleep evaluation Trait anxiety	General Health Q State anxiety Leeds Sleep Evaluation BDI-II POMS	General Health Q State anxiety Leeds Sleep Evaluation BDI-II	General Health Q State anxiety Leeds Sleep Evaluation BDI-II	FFQ General Health Q State anxiety Leeds Sleep Evaluation BDI-II
Other	NEO PI-R WASI				Estimate of compliance

* = Analysis performed for morning participants only

GDS = Geriatric Depression Scale, MMSE = Mini Mental State Examination, DRS = Mattis Dementia Rating Scale, Q = Questionnaire, APOE = Apolipoprotein E, SNP = Single Nucleotide Polymorphisms, WASI = Wechsler Abbreviated Scale of Intelligence FFQ = Food Frequency Questionnaire, NEO PI-R = NEO Personality-Inventory Revised, POMS = Profile of Mood States, BMI = Body Mass Index, CRP = C Reactive Protein, MBA = Multiple Blood Analysis, BP = Blood Pressure, PWV = Pulse Wave Velocity