Table 5.

Treatment options classified by type of infection and clinical picture

Type of NSTI	Depth of involvement	Usual pathogens	Predisposing factors	Time of incubation and rate of progression	The main clinical signs	Treatment options
Polymicrobial NF-type I	fascia and muscle	obligate and facultative anaerobes	different type of wounds	long (48-96 h) Hour to days	foul- smelling drainage	ICU stay critical care therapy surgery antibiotics ev. HBO
Monomicrobial NF-type II (Steptococcal gangrene)	skin, fascia and muscle	Streptococci -groups A, C, G, and B; (B is more common)	excoriation or cut wound	short (6-48 h) A few hour	distinct margins	ICU stay critical care therapy surgery antibiotics ev. HBO
Gas gangrene (Clostridial myonecrosis)	muscle	C. perfirngens (C. perfirngens more common) and C. novyi	tidy wounds	short (6-48 h) A few hour	extreme system toxicity	ICU stay critical care therapy surgery antibiotics HBO
		C. septicum	gastrointestinal lesion
Non-Clostridial myonecrosis	muscle and fascia	obligate and facultative anaerobes or A. hydrophila	different type of wounds	variable (12-96 h) Hour to days	gas in soft tissue	ICU stay critical care therapy surgery antibiotics HBO