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. 2012 Mar 22;8(3):e1002592. doi: 10.1371/journal.pgen.1002592

Figure 4. MetaCore process networks and network maps in autism based on gene deletions located in CNVs from DLPFC, and genetic association results.

Figure 4

Autistic cases had significant enrichment of MetaCore process networks in genes contained within total CNVs (A) and filtered CNVs (i.e., not present in the Database of Genomic Variants) using PennCNV (B) and CNVision (C). Blue bars = controls; red bars = autistic cases. (D) MetaCore network analysis of the top three enriched MetaCore process networks in (B). Symbols in (D) represent gene types or associations. Genes with blue circles were identified autistic CNVs; genes without circles were summoned by the database to complete network. Pink lines = canonical pathway connections. (E) Gene sets tested in set-based association analysis using PLINK in Broad/JHMI and CHOP datasets, number of genes in each set, database from which genes were taken and p-values of associations.