Table 3.
Effect of inhibition of various mitochondrial respiratory complexes on the growth of Scheffersomyces stipitis in glucose and xylose. (--) Complete Inhibition; (-) Partial Inhibition; (0) Negligible; (++) Enhanced; NA - Information not available
| Complex/Inhibitor | Effect on Growth | Effect on Growth Complex formation AOX and Complex III or IV (Predicted from model analysis) | References | ||
|---|---|---|---|---|---|
| Glucose (in Vivo/ In Silico) |
Xylose (in Vivo/ In Silico) |
Glucose (in Vivo/ In Silico) |
Xylose (in Vivo/ In Silico) |
||
| Complex I (Rotenone) |
(--/0) | (-/0) | (--/--) | (-/-) | Shi et al., 2002 |
| Complex III (Antimycin A) |
(NA/-) | (-/-) | (NA/-) | (-/-) | Lighthelm et al., 1988 |
| AOX (SHAM) | (0/0) | (++/0) | (0/0) | (++/++) | Jeppsson et al., 1995 |
| Complex IV (Cyanide) |
(-/-) | (-/-) | (-/-) | (-/-) | Jeppsson et al., 1995 |
| Complex IV and AOX (Sodium Azide) |
(NA/--) | --/--) | (NA/--) | --/--) | Lighthelm et al., 1988 |
| Complex IV(Cyanide) and AOX (SHAM) | (--/--) | (--/--) | (--/--) | (--/--) | Jeppsson et al., 1995 |
| Mutant/Inhibition combination | |||||
| Complex I (Rotenone) + del AOX | (--/0) | (--/0) | (--/--) | (--/--) | Shi et al., 2002 |
| Complex I (Rotenone) + del Complex IV | (--/-) | (--/-) | (--/--) | (--/--) | Shi et al., 2002 |