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Predicted modes of ZFN binding. (a) Binding of a ZFNCTG and ZFNCAG heterodimer capable of cleaving heteroduplex DNA. FokI CD, FokI catalytic domain; ZFPGCT, (GCT)-recognition zinc finger protein; ZFPAGC, (AGC)-recognition zinc finger protein. (b) Predicted modes of ZFNCTG monomer binding to heteroduplex DNA (upper) or homodimeric ZFNCTG capable of cleaving (CTG) hairpin DNA (lower). (Reprinted from [7] with permission)
