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. 2012 Mar 22;7(3):e33241. doi: 10.1371/journal.pone.0033241

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Schreinemacher et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Three weeks after lesion induction, mice were subjected to gadofosveset-trisodium enhanced MRI. A. Examples of T2 weighted anatomical images and T1 weighted prior and post contrast injection in two mice. Lesions are indicated by black arrow-heads (subcutaneous) and white arrow-heads (intraperitoneal). B. DCE-MRI derived intensity time-curves in the large abdominal blood vessels, back muscle, intraperitoneal and subcutaneous lesions. Injection of gadofosveset-trisodium is indicated (arrow-INJ). The inwash (I), circulation (C) and the outwash phases (O) of the contrast agent are indicated. Charts represent the average signal intensity of nine mice plus SD. C. The ratio O/C was assessed in the large abdominal vessels, back muscle and endometriosis. Statistic based on unpaired Wilcoxon test: * = 0.001; **<0.001; ns = non-significant.