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. 2012 Mar 22;7(3):e33340. doi: 10.1371/journal.pone.0033340

Figure 2. The crystallographic structure of the sc-dsFv derived from G6-Fab.

Figure 2

The sc-dsFv structure (colored in green, PDB code 3AUV) is superimposed with the variable domains of VEGF-complexed G6-Fab (2FJG in PDB code, colored in grey) and unbound G6-Fab (2FGF in PDB code, colored in magenta). The interface disulfide bond in the sc-dsFv is marked with the arrow. The RMSDs between the sc-dsFv and the variable domains derived from 2FJF and 2FJG are 0.629 Å and 0.942 Å, respectively. The model of the interface disulfide bond in the sc-dsFv is shown with the superimposition of the Fo-Fc simulated annealing omit density map (colored in cyan) at the 5.0σ level. The omit density map was calculated without the residues of the interface cysteins. The refinement data for the sc-dsFv structure determination are shown in Table S3.