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Experimental time line. Rats were injected with either STZ or saline on Day 0. Seven days later, every other day, intraperitoneal injections of one of four treatment regimens (SAL–SAL, SAL–AMPH, RAC–SAL, or RAC–AMPH) was initiated and continued for 8 d. Two to 4 d later, rats were prepared for either in vivo fMRI or HSCA studies, or killed for ex vivo analyses of ERK activity.
