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. Author manuscript; available in PMC: 2012 Mar 23.
Published in final edited form as: Neuropharmacology. 2008 Jul 3;55(4):474–482. doi: 10.1016/j.neuropharm.2008.06.056

Fig. 4.

Fig. 4

Effects of 3,5-DHPG on the release of [3H]D-aspartate evoked by 12 μM K+ from synaptosomes isolated from the cortex of mouse lacking mGlu1 or mGlu5 receptors. Synaptosomes were prepared from the cortex of transgenic mice lacking mGlu5 receptors (mGlu5−/− mouse, panel A) or mGlu1 receptors (crv4/crv4 mouse, panel B) and from relative controls. Synaptosomes were exposed to 12 μM KCl in absence (white bar) or in presence (grey bar) of 3,5-DHPG (concentration as indicated). Results are expressed as induced overflow. Data are mean ± SEM of 12 experiments run in triplicate. *p < 0.05 at least vs respective control. WT, wild type.