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. Author manuscript; available in PMC: 2012 Mar 23.
Published in final edited form as: Neuropharmacology. 2008 Jul 3;55(4):474–482. doi: 10.1016/j.neuropharm.2008.06.056

Table 1.

Effects of group I mGlu receptor antagonists on the K+-evoked release of [3H]D-ASP from mouse cortical synaptosomes

12 mMK+-evoked release of [3H]D-ASP
(% Induced overflow) (% of Changes vs control)
Control 1.61± 0.13
0.01 μM LY 367385 1.68± 0.09 +4.3
0.01 μM LY 367385 1.62± 0.07 +0.6
0.01 μM LY 367385 1.67± 0.11 +3.7
0.5 μM CPCCOEt 1.72± 0.11 +6.8
5 μM CPCCOEt 1.64± 0.08 +1.8
10 μM CPCCOEt 1.74± 0.26 +0.8
0.3 μM MPEP 1.26± 0.04 −21.8
1 μM MPEP 1.11± 0.11a −31.9
3 μM MPEP 1.52± 0.13 −5.6
5 μM CPCCOEt+1 μM MPEP 1.13± 0.11a −29.9

Results are expressed as % induced overflow or as % of changes respect respective control. Data are means± SEM of at least three experiments run in triplicate.

a

p< 0.05 at least vs control.