Table 2.

Parameters of baclofen-stimulated GTP-binding in the PFC of young and aged F344 rats

Parameter	Young	Aged-Total	Aged-Unimpaired	Aged-Impaired
EMAX (% of young)	100.00 ± 26.08	70.90 ± 8.13	62.81 ± 7.66	80.62 ± 16.58
Log EC50 (M)	−4.44 ± 0.57	−4.73 ± 0.26	−4.86 ± 0.25	−4.53 ± 0.52
Hill Slope (NH)	0.52 ± 0.20*	0.52 ± 0.10***	0.68 ± 0.20a	0.43 ± 0.12**

^*p <0.05,

^**p <0.01,

^***p <0.001 versus N_H=1.

^ap =0.15 versus N_H=1.