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. Author manuscript; available in PMC: 2014 Jun 20.
Published in final edited form as: Int J Cardiol. 2011 Dec 15;166(2):499–504. doi: 10.1016/j.ijcard.2011.11.032

Figure 2. MASP-2 in the coronary and peripheral circulations during global heart ischemia induced by the aortic-cross clamping (AXCL) of open heart surgery.

Figure 2

MASP-2 levels were determined in blood samples taken from 50 patients undergoing open heart surgery. (a) MASP-2 levels in coronary circulation. Coronary sinus blood representing the circulation exiting the myocardium was collected before the start of AXCL and within 5 minutes after AXCL cessation. (b) MASP-2 levels in peripheral circulation. Peripheral blood samples were collected at the following pre-defined time points to document changes due to surgical procedures separate from the effect of AXCL on coronary circulation: 1) pre-surgery/before skin incision; 2) after skin incision/prior to sternotomy; 3) 5 minutes after the beginning of CPB; 4) 5 minutes after the end of AXCL; 5) 5 minutes after CPB cessation; 6) post-surgery day 1; 7) post-surgery day 2. Statistical significances were analyzed as described in Methods. * indicates statistical significance of the respective time point versus the previous time point (P<0.05). Box-charts were plotted as described in Figure 1.