Table 2.
Relationship between blood urea nitrogen and outcome in heart failure studies
| Study | Year | N | Setting | BUN (mg/dL) | Relative risk for mortality |
|---|---|---|---|---|---|
| Lee [25] | 2003 | 4031 | ADHF | 29 ± 19 | 1.49 (1.39–1.60) per 10 units increase |
| Aronson [19] | 2004 | 541 | ADHF | 34 ± 22 | 2.3 (1.3–4.1) for quartiles |
| Heywood [24] | 2005 | 680 | CHF | 29 ± 20 | BUN 30–50: 1.9, BUN >50: 2.2 |
| Shenkman [26] | 2007 | 257 | ADHF | 33 ± 22 | 3.6 (1.8–7.3) per log unit increase |
| Filippatos [21] | 2007 | 302 | ADHF | 31 ± 17 | 1.03 (1.00–1.05) per unit increase |
| Cauthen [20] | 2008 | 444 | CHF | 14 (6–22) | 1.04 (1.03–1.06) per unit increase |
| Klein [27] | 2008 | 949 | CHF | 25 (14–41) | 1.11 (1.07–1.15) per 5 units increase |
| Lin [22] | 2009 | 243 | CHF | 27 ± 17 | 1.24 (1.02–1.51) for BUN-to-creatinine ratio |
| Gotsman [23] | 2010 | 362 | ADHF | 23 (17–29) | 1.80 (1.30–2.49), per tertile BUN/creatinine |
ADHF Acute decompensated heart failure, BUN Blood urea nitrogen, CHF Chronic heart failure