Figure 6.

Schematic representation of the carboxy-terminal tail structures and/or interaction sites present in Kv7 channels. The four helical regions (helices A–D) conserved in all family members are shown as cylinders. Formation of coiled-coil assemblies at the level of helices C and D is indicated. The proposed location of the conserved interaction sites with calmodulin (CaM) and phosphatidylinositol 4,5-bisphosphate (PIP₂), with A-kinase anchoring protein 79/150 (AKAP79/150) in Kv7.2, with the auxiliary β subunit KCNE1 in Kv7.1, with AKAP-Yotiao in Kv7.1, with ankyrin-G in Kv7.2–Kv7.3 and with ubiquitin-protein ligase Nedd4-2 in Kv7.1 and Kv7.2–Kv7.3, are also shown. Phosphorylation sites by Src kinase in helix A and by protein kinase C in helix B are indicated by an encircled P.