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Ovalbumin (OVA) -specific intestinal IgA but not serum IgA or IgG titres are reduced in CD47−/− mice. Wild-type (WT) and CD47−/− mice were fed OVA and cholera toxin (CT) three times. One week later (a) anti-OVA-specific IgA and (b) total IgA in perfused intestines, or (c) anti-OVA-specific IgA and (d) IgG titres in serum were determined. The graphs show titres from four experiments with (a, b, d) at least three mice or (c) two or three mice in each. Error bars show SD.
