Figure 1.

Evolutionary scenario involving asymmetrical evolution after duplication (AED). A schematic view of the AED events included in this study. Using the human gene H_i as a reference, homologs are detected in each vertebrate genome that maintain the same genome neighborhood as the human gene. At the same time, the homologs from each genome with the highest similarity to the human reference gene are identified (full arrows indicate similarity homologs and dashed arrows indicate syntenic homologs). We then selected AED events where the relocated similarity homolog has evolved significantly faster than the local syntenic homolog.