Table 4.
GO term enrichment analysis for artifactual and putative AED events
| GO enrichment for all events | GO enrichment for true events only | ||||
|---|---|---|---|---|---|
| GO ID | GO biological process | P-value | GO ID | GO biological process | P-value |
| 0032501 | multicellular organismal process | 4.E-43 | 0032501 | multicellular organismal process | 2.E-13 |
| 0048856 | anatomical structure development | 2.E-32 | 0050896 | response to stimulus | 9.E-12 |
| 0065007 | biological regulation | 4.E-26 | 0048856 | anatomical structure development | 3.E-09 |
| 0080090 | regulation of primary metabolic process | 6.E-21 | 0042060 | wound healing | 2.E-07 |
| 0071842 | cellular component organization at cellular level | 3.E-20 | 0050789 | regulation of biological process | 1.E-06 |
| 0060255 | regulation of macromolecule metabolic process | 5.E-19 | 0071842 | cellular component organization at cellular level | 2.E-06 |
| 0051171 | regulation of nitrogen compound metabolic process | 5.E-19 | 0007596 | blood coagulation | 4.E-06 |
| 0032774 | RNA biosynthetic process | 5.E-16 | 0022008 | neurogenesis | 5.E-05 |
| 2000112 | regulation of cellular macromolecule biosynthetic process | 7.E-16 | 0006928 | cellular component movement | 6.E-05 |
| 0006139 | nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 1.E-15 | 0030182 | neuron differentiation | 4.E-04 |
| 0010467 | gene expression | 4.E-13 | |||
| 0042060 | wound healing | 4.E-09 | |||
| 0007596 | blood coagulation | 2.E-08 | |||
| 0006810 | transport | 2.E-08 | |||
| 0007166 | cell surface receptor linked signaling pathway | 3.E-06 | |||
| 0007411 | axon guidance | 5.E-06 | |||
| 0007601 | visual perception | 2.E-05 | |||
| 0016477 | cell migration | 5.E-05 | |||
| 0030168 | platelet activation | 1.E-04 | |||
| 0006195 | purine nucleotide catabolic process | 1.E-04 | |||
| 0009207 | purine ribonucleoside triphosphate catabolic process | 5.E-04 | |||
| 0016568 | chromatin modification | 6.E-04 | |||
| 0006915 | apoptosis | 8.E-04 | |||
| 0060173 | limb development | 9.E-04 | |||
Comparison of GO term enrichment analysis for (i) gene list 1 corresponding to 607 predicted asymmetrical evolution events, including both artifactual and putative true events and (ii) 25O true events obtained after filtering the erroneous sequences. GO terms for biological processes were found with P < 10-4 using AmiGO and then filtered with GO-Module (only key terms are shown). Terms that are specific to only one gene list are highlighted in bold.