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. Author manuscript; available in PMC: 2012 Mar 23.
Published in final edited form as: J Biol Chem. 2007 Jun 4;282(31):22879–22886. doi: 10.1074/jbc.M702589200

FIGURE 6. Refolding of the N-subdomain during the transition to an EC.

FIGURE 6

The schematic depicts the movement of the core subdomain (yellow) and refolding of the N-terminal subdomain (red) relative to the C-terminal domain (green) as the transcript length increases from 3 to 9 bp (blue boxes). The C-linker is black. Up to −5 bp movement of the core is apparently tolerated without a need to refold the N-subdomain. A transition at about 6 –7 bp appears to require refolding of at least some parts of the N-subdomain (e.g. the region associated with residues 45–55). Additional movement of the core is expected to occur up to promoter release (commencing at 9 bp) and the final transition to an EC.