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. Author manuscript; available in PMC: 2012 Mar 23.
Published in final edited form as: Stem Cells. 2007 Dec 6;26(3):591–599. doi: 10.1634/stemcells.2007-0439

Figure 1.

Figure 1

Compartments within the umbilical cord. Five separate regions have been shown to contain mesenchymal stromal cells: (1) MSCs can be isolated from 20–50% of freshly prepared mononuclear cell fractions from umbilical cord blood; (2) MSCs have been isolated from umbilical vein subendothelial layer; (3) MSCs can be isolated following enzymatic digestion of the outer layers of umbilical vessels, for example, the perivascular region; (4) intravascular space consistently produces MSCs in healthy individuals; (5) the subamnion region. Wharton’s jelly includes zones 3 through 5. This review focuses on Wharton’s jelly-derived cells and not on MSCs derived from umbilical cord blood (zone 1) or umbilical vein subendothelium (zone 2).