Table 1.
MSCs in umbilical cord and cord blood
| Zone | Designation | Acronym | Reference | Differentiation potential in vitro | Differentiation in vivo | Cells supported by UCMS | Trophic effect in vivo |
|---|---|---|---|---|---|---|---|
| 1 | Umbilical cord blood-derived multilineage progenitor cells | MLPC | Berger MJ, et al., 2006 | Endodermal differentiation, specifically respiratory epithelium type II alveolar cells | |||
| 1 | Mesenchymal stem cell-like cells | MSC-like cells | Bieback K, et al., 2004 | A (weak), B, C | |||
| 1 | Mesenchymal-like cells | MLCs | Erices A, et al., 2000 | A, B | |||
| 1 | Umbilical cord blood-derived mesenchymal stem cells | UCB-derived MSCs | Gang EJ, et al., 2004 | SM | |||
| 1 | Umbilical cord blood-derived mesenchymal stem cells | UCB-derived MSCs | Gang EJ, et al., 2006 | Endothelial markers | Expanded CD34+ cells in vitro | ||
| 1 | Umbilical cord blood-derived stromal cell | Gao L, et al., 2006 | |||||
| 1 | Non-hematopoietic progenitors | NHPs | Goodwin HS, et al., 2001 | A (weak), B, N | |||
| 1 | Hong SH, et al., 2005 | ||||||
| 1 | MSC from umbilical cord blood | MSCs | Hou L, et al., 2003 | N | |||
| 1 | Umbilical cord blood-derived mesenchymal stem cells | UCB-derived MSCs | Jang YK, et al., 2006 | A, B, C | Expanded total and CD34+ cells in vitro | ||
| 1 | Human umbilical cord blood-derived mesenchymal stem cells | MSCs | Jeong JA, et al., 2005 | ||||
| 1 | Kang XQ, et al., 2006 | ||||||
| 1 | AC133-CD14+ umbilical cord blood-derived cells | AC133-CD14+ cells | Kim SY, et al., 2005 | Endothelial markers | |||
| 1 | Umbilical cord blood-derived mesenchymal stem cells | UCB-MSCs | Kern S, et al., 2006 | A (could not differentiate to A), B, C | |||
| 1 | Unrestricted somatic stem cells from human cord blood | USSC | Kogler G, et al., 2004 | A, B, C, N | B, C, hematopoietic, cardiac tissue, liver cells, neural cells | ||
| 1 | Multipotent mesenchymal stem cells from umbilical cord blood | Lee OK, et al., 2004 | A, B, C, N, hepatogenic differentiation | ||||
| 1 | Umbilical cord blood-derived mesenchymal stem cells | UCB-MSCs | Lu FZ, et al., 2005 | A, B | |||
| 1 | Cord blood derived-mesenchymal stem cells | CB-MSC | Wagner W, et al., 2005 | A (reduced/absent), B, C | |||
| 1 | Human mesenchymal stem/progenitor cell | Wang J-F, et al., 2004 | C | Expanded CD34+ cells in vitro | |||
| 1 | Human mesenchymal stem/progenitor cell | MSPC | Yang S-E, et al., 2004 | ||||
| 1 | Human umbilical cord blood stromal cells | HUCB-derived adherent layer cultures | Ye ZQ, et al., 1994 | Reduced or lacked adipocytes | Expanded total MNCs in vitro | ||
| 1 | Fetal blood derived mesenchymal stem cells | - | Yu M, et al., 2004 | A (reduced), B, N | |||
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| 2 | Umbilical vein mesenchymal stem cells | Covas DT, et al., 2003 | A, B | ||||
| 2 | Mesenchymal progenitor or stem cells, fibroblastic and endothelial cells isolated | Kim JW, et al., 2004 | A, B | ||||
| 2 | Umbilical cord-mesenchymal stem cells | UC-MSCs | Panepucci RA, et al., 2004 | A, B, C | |||
| 2 | Mesenchymal stem cell-like cells | MSC-like cells | Romanov YA, et al., 2003 | A, B | |||
| 2 | Umbilical fibroblast-like cells | Yarygin KN, et al, 2006 | Endothelial precursors | 2 wk survival no disorders noted | Hematopoietic stem cells from cord blood | ||
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| 3 | Human umbilical cord perivascular cells | HUCPVCs | Baksh K, et al., 2007 | A, B, C | |||
| 3 | Human umbilical cord perivascular cells | HUCPV cells | Sarugaser R, et al., 2005 | B | |||
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| 4 | Human umbilical cord matrix cells | HUCM | Bailey MM, et al., 2007 | Cartilage | |||
| 4 | CD105+/CD31−/KDR− cells | None given | Conconi MT, et al., 2006 | A, B, SM | SM for 14 d | ||
| 4 | Umbilical cord mesenchymal cells | None given | Fu Y-S, et al., 2004 | Neuron-like and glia | |||
| 4 | Human umbilical mesenchymal stem cells | HUMSCs | Fu Y-S, et al., 2006 | N (dopaminergic, noradrenergic, GABAergic marker expression) | N (TH+, DBH+, GD+ staining 20 wks survival) | Behavioral recovery in PD model | |
| 4 | Rat umbilical cord matrix cells | RUCMs | Jomura, S, et al., 2006 | Rescue of CA1 neurons following stroke | |||
| 4 | Umbilical cord cells | UCC | Kadner A et al., 2002 | ||||
| 4 | Whole umbilical cord | WUCC | Kadner A et al., 2004 | ||||
| 4 | Human umbilical cord stroma cell, intervascular cells (IVCs) vs perivascular cells (PVCs) | HUCSCs | Karahuseyinoglu, S, et al., 2006 | A (reduced), B, C, N | |||
| 4 | Mesenchymal stem cells derived from umbilical cord | UC-MSC | Lu L-L, et al, 2006 | A, B, N | Expanded allogeneic cord blood CD34+ cells in vitro | ||
| 4 | Human umbilical cord-derived cells | hUTC | Lund RD, et al., 2007 | Rescue of retinal photoreceptor cells | |||
| 4 | Wharton’s Jelly mesenchymal stem cells | Ma L, et al., 2005 | N | ||||
| 4 | Pig umbilical cord matrix’ stem cells | UCM cells | Medicetty S, et al., 2004 | N (TH+ cells), brain engraftment 8 wk survival | |||
| 4 | Wharton’s jelly cells | Mitchell K, et al., 2003 | N (neuronal and glial markers) | ||||
| 4 | Umbilical cord matrix stem cells | UCMSCs | Rachakatla RS, et al., 2007 | Homing to lung cancer tumors | |||
| 4 | Bovine umbilical cord-derived fibroblasts | Saito S, et al., 2003 | Supported equine ES- like cells | ||||
| 4 | Wharton’s Jelly-derived myofibroblast cells | WMFs | Schmidt D, et al., 2006 | Subendothelial marker, collagen | |||
| 4 | Mesenchymal cells in Wharton’s jelly | Wang H-S, et al., 2004 | A (varying degrees), B, C, cardio (markers) | ||||
| 4 | Umbilical cord matrix cells | UCM cells | Weiss ML, et al., 2003 | N (neuronal markers) | N (neural markers), engraftment in kidney and muscle 3wk survival | ||
| 4 | Umbilical matrix stem cells | UCMS cells | Weiss ML, et al., 2006 | N (neuronal markers) | Rescue of SN neurons in PD model | ||
| 4 | Umbilical cord-derived stem cells | UCDS | Wu KH, et al., 2007 | A (variable), B, endothelial cells | Endothelial cells 4 wk survival (CD34+ cells) | Supported revascularization of ischaemic limb | |
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| 5 | Coppi P, et al., 2007 | A, B, SM, N, endothelial and hepatic markers | Brain engraftment 8-week survival, hepatic engraftment with marker expression, bone engraftment with calcification | ||||
| 5 | Chiavegato A, et al., 2007 | ||||||
Abbreviations: A, adipose; B, bone; C, cartilage; Cardio, cardiac muscle; H, hematopoietic stem cells; N, neural endothelial markers; SM, skeletal muscle.